Histomorphometric study on the effect of low dose deltamethrin on the developing cerebellar cortex

Deltamethrin, first discovered in 1974, is a widely used type II pyrethroid-based synthetic insecticide (1). As a group, pyrethroids are regarded as safer for humans than the other classes of insecticide (2). Deltamethrin is widely used in the agricultural sector, as it has high efficacy against a large number of insects. Its low toxicity to humans has made it one of the insecticides of choice in many countries (3). Deltamethrin acts on the nervous system via its interaction with various channels and receptors, although its primary target is the voltage-dependent sodium channels (4). Its neurotoxicity in adults is well characterized, although information regarding its developmental neurotoxicity is still limited (5).